Mapping the Landscape of Recent Studies on Pyrimidine Derivatives as Antimicrobial Agents: A Bibliometric Analysis
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Abstract
Background: Recently, microbes have become resistant to various drugs and this resistance is considered a big challenge in the treatment of infectious diseases. Therefore, there is a fundamental need to develop new drugs to treat resistant microbes. Having different biological effects, pyrimidine is an effective ring in the structure of drugs with antimicrobial effects. There hasn't been a bibliometric analysis in this area despite the field's incredible progress in the last 10 years in the study of pyrimidine as an antimicrobial agent.
Methods: A comprehensive examination of the available literature published between 2015 and 2023 on pyrimidine derivatives as antimicrobial agents was done across the Scopus database. Microsoft Excel 365 was employed to analyze the quantitative variables, such as publications and citation counts, for the authors, institutions, countries, and journals, the powerful tool. Furthermore, the network visualization and analysis of co-authorship, co-occurrence, and co-citation among countries, institutions, authors, and keywords were facilitated by VOSviewer.
Results: A total of 934 articles were selected for the study. The years 2019 and 2022 exhibited the highest volume of published papers on pyrimidine derivatives as antimicrobial agents between 2015 and 2023, with 125 publications each. A total of 53 countries contributed to the topic, with India leading in publications, followed by Egypt, China, Saudi Arabia, and the United States. Among journals, the Journal of Heterocyclic Chemistry had the highest number of publications (n=50), followed by the European Journal of Medicinal Chemistry with 37 publications.
Conclusion: The findings provide valuable insights for researchers in selecting specific compounds for their upcoming studies, emphasizing the significance of bibliometric analysis in shaping the trajectory of research in the field of pyrimidine antimicrobial research.
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