Sensitivity Pattern of the Candida Species Separated from the Blood and Urine of the Patients with Malignancy in Hospital
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Abstract
Background: Infection with Candida species has been increased globally during the past decade. This can be due to the increase in the number of patients with immunodeficiency problems like cancer, HIV AIDs, organ transplantation and hospitalization in ICUs. We aimed to investigate the prevalence rate of the fungal colonization and related species in chemotherapy-subjected children with malignancy.
Methods: Present analytical-applied research was conducted on 128 chemotherapy-subjected children with malignancy. Blood and urine samples were collected from all the patients; afterwards, the urine samples were cultivated on Saborrads Dextrose Agar and the blood samples in ordinary culture bottles (monophasic culture method and blood culturing). Then, the developed fungi were separated from the culture medium and subjected to identification tests.
Results: There was no significant relationship between the age group and infection with fungus (P=0.998) but there was a significant relationship between gender and fungus infection (P=0.049) in such a way that fungus infection was found more prevalent amongst the females. Overall, 28 individuals (58.33%) were found infected with C. albicans; 9 (18.75%) with C. tropicalis; 5 (10.42%) with C. glabrata; 3 (6.25%) with C. kefir; 2 (4.116%) with C. krusei and 1 (2.09%) with C. parapsilosis.
Conclusion: C. albicans is the most common species in this geographical area. The best treatment for these infectious diseases is voriconazole.
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References
Mundula T, Ricci F, Barbetta B, Baccini M, Amedei A. Effect of Probiotics on Oral Candidiasis: A Systematic Review and Meta-Analysis. Nutrients. 2019; 11(10).
Ejaz H, Ramzan M. Determination of minimum inhibitory concentrations of various antifungal agents in clinical isolates of Candida species. J Pak Med Assoc. 2019; 69(8):1131-1135.
Sganga G, Wang M, Capparella MR, Tawadrous M, Yan JL, Aram JA, et al. Evaluation of anidulafungin in the treatment of intra-abdominal candidiasis: a pooled analysis of patient-level data from 5 prospective studies. Eur J Clin Microbiol Infect Dis. 2019; 38(10):1849-1856.
Poissy J, Damonti L, Bignon A, Khanna N, Von Kietzell M, Boggian K, et al. Risk factors for candidemia: a prospective matched case-control study. Crit Care. 2020 18; 24(1):109.
Altintop YA, Ergul AB, Koc AN, Atalay MA. Evaluation of Candida colonization and use of the Candida Colonization Index in a paediatric Intensive Care Unit: a prospective observational study. Infez Med. 2019;27(2):159-167.
Zeng ZR, Tian G, Ding YH, Yang K, Liu JB, Deng J. Surveillance study of the prevalence, species distribution, antifungal susceptibility, risk factors and mortality of invasive candidiasis in a tertiary teaching hospital in Southwest China. BMC Infect Dis. 2019 Nov 7; 19(1):939.
Zhang W, Song X, Wu H, Zheng R.Epidemiology, risk factors and outcomes of Candida albicans vs. non-albicans candidaemia in adult patients in Northeast China. Epidemiol Infect. 2019 Sep 25; 147:e277.
Medeiros MAP, Melo APV, Bento AO, Souza LBFC, Neto FAB, Garcia JB, et al. Epidemiology and prognostic factors of nosocomial candidemia in Northeast Brazil: A six-year retrospective study. PLoS One. 2019 Aug 22; 14(8):e0221033.
Aldardeer NF, Albar H, Al-Attas M, Eldali A, Qutub M, Hassanien A, et al. Antifungal resistance in patients with Candidaemia: a retrospective cohort study. BMC Infect Dis. 2020 Jan 17;20(1):55.
Corcione S, D'Avolio A, Pasero D, Trentalange A, Pagani N, Sanguinetti M, et al. Acquisition of FKS2 mutation after echinocandin treatment of infective endocarditis by Candida glabrata. Infez Med. 2019 Sep 1; 27(3):328-331.
Ramos JT, Romero CA, Belda S, Candel FJ, Carazo Gallego B, Fernández-Polo A, et al. Clinical practice update of antifungal prophylaxis in immunocompromised children. Rev Esp Quimioter. 2019 Oct;32(5):410-425.
Hamzavi SS, Amanati A, Badiee P, Kadivar MR, Jafarian H, Ghasemi F, et al. Changing face of Candida colonization pattern in Pediatric patients with hematological malignancy during repeated hospitalizations, results of a prospective observational study (2016-2017) in shiraz, Iran. BMC Infect Dis. 2019 Aug 30;19(1):759.
Brunetti G, Navazio AS, Giuliani A, Giordano A, Proli EM, Antonelli G, et al. Candida blood stream infections observed between 2011 and 2016 in a large Italian University Hospital: A time-based retrospective analysis on epidemiology, biofilm production, antifungal agents consumption and drug-susceptibility. PLoS One. 2019 Nov 7; 14(11):e0224678.
Rodrigues LS, Motta FA, Picharski GL, Vasconcelos TM, Riccieri MC, Dalla-Costa LM. Invasive candidiasis: Risk factor for mortality in a pediatric tertiary care hospital in south of Brazil. Medicine (Baltimore). 2019 Jun; 98(23):e15933.
Mroczyńska M, Brillowska-Dabrowska A. First report on echinocandin resistant Polish Candida isolates. Acta Biochim Pol. 2019 Sep 12; 66(3):361-364.
Keighley C, Chen SC, Marriott D, Pope A, Chapman B, et al. Candidaemia and a risk predictive model for overall mortality: a prospective multicentre study. BMC Infect Dis. 2019 May 21;19(1):445.
Benedict K, Roy M, Kabbani S, Anderson EJ, Farley MM, Harb S, et al. Neonatal and Pediatric Candidemia: Results From Population-Based Active Laboratory Surveillance in Four US Locations, 2009-2015. J Pediatric Infect Dis Soc. 2018 Aug 17;7(3):e78-e85.
Ruijters VJ, Oosterom N, Wolfs TFW, van den Heuvel-Eibrink MM, van Grotel M. Frequency and Determinants of Invasive Fungal Infections in Children With Solid and Hematologic Malignancies in a Nonallogeneic Stem Cell Transplantation Setting: A Narrative Review. J Pediatr Hematol Oncol. 2019 Jul;41(5):345-354.
Almooosa Z, Ahmed GY, Omran A, AlSarheed A, Alturki A, Alaqeel A, et al. Invasive Candidiasis in pediatric patients at King Fahad Medical City in Central Saudi Arabia. A 5-year retrospective study. Saudi Med J. 2017 Nov; 38(11):1118-1124.
Kishimoto K, Kasai M, Kawamura N, Ito Y, Yoshida M, Hasegawa D, et al.Clinical features in proven and probable invasive fungal disease in children and adolescents at a pediatric referral center: a 5-year experience. World J Pediatr. 2019 Jun;15(3):270-275.
Widmer AF, Kern WV, Roth JA, Dettenkofer M, Goetting T, Bertz H, et al. Early versus late onset bloodstream infection during neutropenia after high-dose chemotherapy for hematologic malignancy. Infection. 2019 Oct;47(5):837-845.
He YZ, Guo XJ, Lin XY, Zhu HB. [Analysis of Risk Factors Affecting the Chemotherapy-related Infections in Patients with ALL]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Dec;27(6):1825-1830.
Fisher BT, Robinson PD, Lehrnbecher T, Steinbach WJ, Zaoutis TE, Phillips B, et al.Risk Factors for Invasive Fungal Disease in Pediatric Cancer and Hematopoietic Stem Cell Transplantation: A Systematic Review. J Pediatric Infect Dis Soc. 2018 Aug 17;7(3):191-198.
Linke C, Tragiannidis A, Ahlmann M, Fröhlich B, Wältermann M, Burkhardt B, et al. Epidemiology and management burden of invasive fungal infections after autologous hematopoietic stem cell transplantation: 10-year experience at a European Pediatric Cancer Center. Mycoses. 2019 Oct;62(10):954-960.
Lin GL, Chang HH, Lu CY, Chen CM, Lu MY, Lee PI,et al. Clinical characteristics and outcome of invasive fungal infections in pediatric acute myeloid leukemia patients in a medical center in Taiwan. J Microbiol Immunol Infect. 2018 Apr;51(2):251-259.
Giamarellos-Bourboulis EJ, Stamou A, Maraki S, Solomonidi N, Belesiotou E, Pistiki A, et al. Susceptibility profiles and clinical efficacy of antifungals against Candida bloodstream isolates from critically ill patients: Focus on intravenous itraconazole. Int J Antimicrob Agents. 2019 Oct;54(4):471-477.
Xiao M, Sun ZY, Kang M, Guo DW, Liao K, Chen SC, et al.Five-Year National Surveillance of Invasive Candidiasis: Species Distribution and Azole Susceptibility from the China Hospital Invasive Fungal Surveillance Net (CHIF-NET) Study. J Clin Microbiol. 2018 Jun 25;56(7). pii: e00577-18.
Gamaletsou MN, Walsh TJ, Sipsas NV. Invasive Fungal Infections in Patients with Hematological Malignancies: Emergence of Resistant Pathogens and New Antifungal Therapies. Turk J Haematol. 2018 Mar 1;35(1):1-11.
Hirano R, Minakawa S, Kitazawa J, Saito N, Kayaba H. Impact on Antifungal Susceptibility Patterns of Previous vs. Revised Clinical and Laboratory Standards Institute Breakpoints for Candida Species Isolated from Candidemia: Experience of Two Tertiary Care Institutions in Japan. Clin Lab. 2019 Jul 1;65(7).
Tsai MH, Hsu JF, Yang LY, Pan YB, Lai MY, Chu SM, et al.Candidemia due to uncommon Candida species in children: new threat and impacts on outcomes. Sci Rep. 2018 Oct 15;8(1):15239.
Epstein DJ, Seo SK, Brown JM, Papanicolaou GA. Echinocandin prophylaxis in patients undergoing haematopoietic cell transplantation and other treatments for haematological malignancies. J Antimicrob Chemother. 2018 Jan 1;73(suppl_1):i60-i72.